Erik ten Hag has included Noussair Mazraoui in his starting XI, giving the Morocco international his United debut just three days after signing from Bayern Munich.
Fellow summer signings Matthijs de Ligt and Joshua Zirkzee start on the bench and could also make their United debuts if brought on. Along with Leny Yoro, the trio will be introduced to the crowd before kick-off.
Mazraoui replaces Jonny Evans in the only change from Saturday’s Community Shield clash with Manchester City at Wembley. In defense, Harry Maguire partners Lisandro Martinez in front of Andre Onana, with Diogo Dalot occupying the other full-back position.
Casemiro and Kobbie Mainoo start in midfield, supporting a fluid attack of Amad, Mason Mount, Marcus Rashford, and Bruno Fernandes.
United’s starting XI: Onana; Mazraoui, Maguire, Martinez, Dalot; Casemiro, Mainoo; Amad, Mount, Rashford; Fernandes (c).
Substitutes: Bayindir, De Ligt, Evans, Eriksen, McTominay, Collyer, Antony, Zirkzee, Garnacho.
Fulham’s starting XI: Leno (c); Tete, Diop, Bassey, Robinson; Lukic, Pereira; Adama, Smith Rowe, Iwobi; Muniz.
Substitutes: Benda, Castagne, Cuenca, Cairney, Reed, King, Jimenez, Stansfield, Wilson.